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Sean J Morrison, University of Texas Southwestern Medical Center Read More + These mice possess lox P sites on either side of the exon 3-5 region of the targeted gene.Mice homozygous for this allele are viable and fertile and do not display any gross physical or behavioral abnormalities.
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When crossed with a Cre recombinase-expressing strain, this strain carrying a floxed allele is useful in eliminating tissue-specific expression of the gene.
This mutant mouse strain may be useful in studies of fetal and neonatal hematopoietic stem cells and hematopoiesis.